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ERCC1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant ERCC1.

  • WB - ERCC1 Antibody (monoclonal) (M01) AT1936a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (33.99 KDa) .
  • IF - ERCC1 Antibody (monoclonal) (M01) AT1936a
    Immunofluorescence of monoclonal antibody to ERCC1 on HeLa cell . [antibody concentration 10 ug/ml]
  • E - ERCC1 Antibody (monoclonal) (M01) AT1936a
    Detection limit for recombinant GST tagged ERCC1 is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07992
Other Accession BC052813
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3A7
Calculated MW 32562 Da
Additional Information
Gene ID 2067
Other Names DNA excision repair protein ERCC-1, ERCC1
Target/Specificity ERCC1 (AAH52813, 207 a.a. ~ 281 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsERCC1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.


Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer. Palli D, et al. Mutagenesis, 2010 Sep 3. PMID 20817763.Detection of ERCC1 118 polymorphisms in non-small-cell lung cancer by an improved fluorescence polarization assay. Wenchao L, et al. Diagn Mol Pathol, 2010 Sep. PMID 20736746.[Association between polymorphisms of ERCC1 and response in patients with advanced non-small cell lung cancer receiving cisplatin-based chemotherapy] Wang J, et al. Zhongguo Fei Ai Za Zhi, 2010 Apr. PMID 20677561.[The clinical signifcance of expression of ERCC1 and PkCalpha in non-small cell lung cancer] He L, et al. Zhongguo Fei Ai Za Zhi, 2010 Mar. PMID 20673527.[The expression and prognostic significance of ERCC1 and GST-pi in lung cancer] Xu C, et al. Zhongguo Fei Ai Za Zhi, 2010 Mar. PMID 20673515.

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$ 315.00
Cat# AT1936a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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