ESM1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant ESM1.
|Application ||WB, IHC, E|
|Calculated MW||20095 Da|
|Other Names||Endothelial cell-specific molecule 1, ESM-1, ESM1|
|Target/Specificity||ESM1 (NP_008967, 85 a.a. ~ 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ESM1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene.
1.ESM-1 silencing decreased cell survival, migration, and invasion and modulated cell cycle progression in hepatocellular carcinoma.Kang YH, Ji NY, Lee CI, Lee HG, Kim JW, Yeom YI, Kim DG, Yoon SK, Kim JW, Park PJ, Song EY.Amino Acids. 2010 Sep 7. [Epub ahead of print]2.Identification of endothelial cell-specific molecule-1 as a potential serum marker for colorectal cancer.Ji NY, Kim YH, Jang YJ, Kang YH, Lee CI, Kim JW, Yeom YI, Chun HK, Choi YH, Kim JH, Kim JW, Lee HG, Song EY.Cancer Sci. 2010 Jul 30. [Epub ahead of print]3.Overexpression of Endothelial Cell Specific Molecule-1 (ESM-1) in Gastric Cancer.Liu N, Zhang LH, Du H, Hu Y, Zhang GG, Wang XH, Li JY, Ji JF.Ann Surg Oncol. 2010 Apr 10. [Epub ahead of print]
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