F11R Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant F11R.
|Application ||WB, IHC, E|
|Calculated MW||32583 Da|
|Other Names||Junctional adhesion molecule A, JAM-A, Junctional adhesion molecule 1, JAM-1, Platelet F11 receptor, Platelet adhesion molecule 1, PAM-1, CD321, F11R, JAM1, JCAM|
|Target/Specificity||F11R (AAH01533, 1 a.a. ~ 299 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||F11R Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
1.Low JAM-A expression correlates with poor prognosis in gastric cancer.Huang JY, Xu YY, Sun Z, Wang ZN, Zhu Z, Song YX, Luo Y, Zhang X, Xu HM.Journal of Surgical Research (2014), doi: 10.1016/j.jss.2014.06.025.2.Low Expression of Junctional Adhesion Molecule A Is Associated with Metastasis and Poor Survival in Pancreatic Cancer.Fong D, Spizzo G, Mitterer M, Seeber A, Steurer M, Gastl G, Brosch I, Moser P.Ann Surg Oncol. 2012 May 2.3.JAM-A expression positively correlates with poor prognosis in breast cancer patients.McSherry EA, McGee SF, Jirstrom K, Doyle EM, Brennan DJ, Landberg G, Dervan PA, Hopkins AM, Gallagher WM.Int J Cancer. 2009 Sep 15;125(6):1343-51.4.Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma.Gutwein P, Schramme A, Voss B, Abdel-Bakky MS, Doberstein K, Ludwig A, Altevogt P, Hansmann ML, Moch H, Kristiansen G, Pfeilschifter J.Biochem Biophys Res Commun. 2009 Mar 6;380(2):387-91. Epub 2009 Jan 23.
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