FAIM3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant FAIM3.
|Application ||WB, E|
|Calculated MW||43146 Da|
|Other Names||Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso, FAIM3, TOSO|
|Target/Specificity||FAIM3 (AAH06401, 124 a.a. ~ 223 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FAIM3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).
1.Toso, a Functional IgM Receptor, Is Regulated by IL-2 in T and NK Cells.Murakami Y, Narayanan S, Su S, Childs R, Krzewski K, Borrego F, Weck J, Coligan JE.J Immunol. 2012 Jun 6.2.Enhanced levels of both membrane-bound and soluble forms of IgM Fc receptor in patients with chronic lymphocytic leukemia.Li FJ, Kubagawa Y, McCollum MK, Wilson L, Motohashi T, Bertoli LF, Barton JC, Barnes S, Davis RS, Kubagawa H.Blood. 2011 Sep 9.3.SAGE analysis demonstrates increased expression of TOSO contributing to Fas mediated resistance in CLL.Proto-Siqueira R, Panepucci RA, Careta FP, Lee A, Clear A, Morris K, Owen C, Rizzatti EG, Silva-Jr WA, Falcao RP, Zago MA, Gribben JG.Blood. 2008 Jul 15;112(2):394-7. Epub 2008 Apr 23.
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