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FANCG Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant FANCG.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IP |
|---|---|
| Primary Accession | O15287 |
| Other Accession | BC011623 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 2C8 |
| Calculated MW | 68554 Da |
| Gene ID | 2189 |
|---|---|
| Other Names | Fanconi anemia group G protein, Protein FACG, DNA repair protein XRCC9, FANCG, XRCC9 |
| Target/Specificity | FANCG (AAH11623, 1 a.a. ~ 622 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FANCG Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G.
References
1.Areca Nut Induces miR-23a and Inhibits Repair of DNA Double-Strand Breaks by Targeting FANCG.Tsai YS, Lin CS, Chiang SL, Lee CH, Lee KW, Ko YC.Toxicol Sci. 2011 Oct;123(2):480-90. Epub 2011 Jul 12.2.Stimulation of Homology-directed Repair at I-SceI-induced DNA breaks during the Permissive Life Cycle of Human Cytomegalovirus.Kulkarni AS, Fortunato EA.J Virol. 2011 Apr 13. [Epub ahead of print]3.Four human FANCG polymorphic variants show normal biological function in hamster CHO cells.Hinz JM, Nham PB, Yamada NA, Tebbs RS, Salazar EP, Hinz AK, Mohrenweiser HW, Jones IM, Thompson LH.Mutat Res. 2006 Dec 1;602(1-2):34-42. Epub 2006 Sep 28.
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