FBXL10 Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant FBXL10.
|Application ||WB, IF, E|
|Calculated MW||152615 Da|
|Other Names||Lysine-specific demethylase 2B, CXXC-type zinc finger protein 2, F-box and leucine-rich repeat protein 10, F-box protein FBL10, F-box/LRR-repeat protein 10, JmjC domain-containing histone demethylation protein 1B, Jumonji domain-containing EMSY-interactor methyltransferase motif protein, Protein JEMMA, Protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, KDM2B, CXXC2, FBL10, FBXL10, JHDM1B, PCCX2|
|Target/Specificity||FBXL10 (NP_115979, 457 a.a. ~ 555 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FBXL10 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
1.JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M.Nature. 2007 Nov 8;450(7167):309-13.
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