FCN1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant FCN1.
|Application ||WB, E|
|Calculated MW||35078 Da|
|Other Names||Ficolin-1, Collagen/fibrinogen domain-containing protein 1, Ficolin-A, Ficolin-alpha, M-ficolin, FCN1, FCNM|
|Target/Specificity||FCN1 (NP_001994, 201 a.a. ~ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FCN1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.
Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain. Honor? C, et al. J Leukoc Biol, 2010 Jul. PMID 20400674.Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma. Wittenborn T, et al. J Innate Immun, 2010 Feb. PMID 20375634.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. Gout E, et al. J Biol Chem, 2010 Feb 26. PMID 20032467.Binding site of C-reactive protein on M-ficolin. Tanio M, et al. Mol Immunol, 2009 Dec. PMID 19853918.
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