FGL2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant FGL2.
|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||50229 Da|
|Other Names||Fibroleukin, Fibrinogen-like protein 2, pT49, FGL2|
|Target/Specificity||FGL2 (NP_006673, 24 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FGL2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites.
The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. Liu Y, et al. Biochem Biophys Res Commun, 2010 May 28. PMID 20438701.Candidate genes associated with susceptibility for SARS-coronavirus. Hsieh YH, et al. Bull Math Biol, 2010 Jan. PMID 19590927.Severe acute respiratory syndrome coronavirus nucleocapsid protein does not modulate transcription of the human FGL2 gene. Siu KL, et al. J Gen Virol, 2009 Sep. PMID 19423547.Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma. Su K, et al. World J Gastroenterol, 2008 Oct 21. PMID 18932275.Hepatitis B virus-induced hFGL2 transcription is dependent on c-Ets-2 and MAPK signal pathway. Han M, et al. J Biol Chem, 2008 Nov 21. PMID 18801734.
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