FIS1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant FIS1.
|Application ||WB, IHC, E|
|Calculated MW||16938 Da|
|Other Names||Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11|
|Target/Specificity||FIS1 (AAH03540.1, 1 a.a. ~ 152 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FIS1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).
Specific mitochondrial calcium overload induces mitochondrial fission in prostate cancer cells. Kaddour-Djebbar I, et al. Int J Oncol, 2010 Jun. PMID 20428767. Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. Mai S, et al. J Cell Sci, 2010 Mar 15. PMID 20179104. Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1. Serasinghe MN, et al. J Biol Chem, 2010 Jan 1. PMID 19864424. The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction. Serasinghe MN, et al. Exp Cell Res, 2008 Nov 15. PMID 18845145. Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. Park KS, et al. J Biol Chem, 2008 Nov 28. PMID 18832378.
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