FKBP10 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant FKBP10.
|Application ||WB, E|
|Calculated MW||64245 Da|
|Other Names||Peptidyl-prolyl cis-trans isomerase FKBP10, PPIase FKBP10, 65 kDa FK506-binding protein, 65 kDa FKBP, FKBP-65, FK506-binding protein 10, FKBP-10, Immunophilin FKBP65, Rotamase, FKBP10, FKBP65|
|Target/Specificity||FKBP10 (NP_068758, 377 a.a. ~ 470 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FKBP10 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.
Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. Alanay Y, et al. Am J Hum Genet, 2010 Apr 9. PMID 20362275.Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Svendsen JM, et al. Cell, 2009 Jul 10. PMID 19596235.The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens. Ishikawa Y, et al. J Biol Chem, 2008 Nov 14. PMID 18786928.Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). Foster LJ, et al. J Proteome Res, 2006 Jan. PMID 16396496.Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin. Patterson CE, et al. Cell Stress Chaperones, 2005 Winter. PMID 16333983.
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