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FRZB Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full length recombinant FRZB.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q92765 |
| Other Accession | NM_001463 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1H8 |
| Calculated MW | 36254 Da |
| Gene ID | 2487 |
|---|---|
| Other Names | Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1, FRZB, FIZ, FRE, FRP, FRZB1, SFRP3 |
| Target/Specificity | FRZB (NP_001454, 102 a.a. ~ 190 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FRZB Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
References
Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. Zintzaras E, et al. Am J Epidemiol, 2010 Apr 15. PMID 20237151.The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Kongkham PN, et al. Oncogene, 2010 May 20. PMID 20208569.Role of secreted frizzled-related protein 3 in human renal cell carcinoma. Hirata H, et al. Cancer Res, 2010 Mar 1. PMID 20160027.Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Xu J, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080650.No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families. Gao G, et al. BMC Med Genet, 2010 Jan 1. PMID 20043861.
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