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FXR1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant FXR1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P51114 |
| Other Accession | BC028983 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2G11 |
| Calculated MW | 69721 Da |
| Gene ID | 8087 |
|---|---|
| Other Names | Fragile X mental retardation syndrome-related protein 1, hFXR1p, FXR1 |
| Target/Specificity | FXR1 (AAH28983, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FXR1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
References
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. International Schizophrenia Consortium, et al. Nature, 2009 Aug 6. PMID 19571811.Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Darnell JC, et al. Hum Mol Genet, 2009 Sep 1. PMID 19487368.Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients. Davidovic L, et al. J Med Genet, 2008 Oct. PMID 18628314.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Vasudevan S, et al. Cell, 2007 Mar 23. PMID 17382880.
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