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GADD45G Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT2146a | 50 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
GADD45G Antibody (monoclonal) (M01) - Product info | |
| Primary Accession | O95257 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 1D3 |
| Calculated MW | 17121 Da |
GADD45G Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 10912 | |
| Other Names CR6, DDIT2, GADD45gamma, GRP17growth arrest and DNA-damage-inducible, gamma | |
| Target/Specificity GADD45G (AAH19325, 1 a.a. ~ 160 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions GADD45G Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
GADD45G Antibody (monoclonal) (M01) - Related products
RI12121: GADD45G predesign siRNA
GADD45G Antibody (monoclonal) (M01) - Application data
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Detection limit for recombinant GST tagged GADD45G is approximately 0.03ng/ml as a capture antibody.
GADD45G Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.
REFERENCES
Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis. Zhang W, et al. J Cancer Res Clin Oncol, 2010 Aug. PMID 20111973.Urinary GADD45gamma expression is associated with progression of lgA nephropathy. Yu S, et al. Am J Nephrol, 2009. PMID 19293565.Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Palmieri RT, et al. Cancer Epidemiol Biomarkers Prev, 2008 Dec. PMID 19064572.Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells. Zhu N, et al. Mol Biol Rep, 2009 Nov. PMID 19048389.Purification, crystallization and preliminary X-ray diffraction analysis of human Gadd45gamma. Zhang W, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Nov 1. PMID 18997345.
