GATA3 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant GATA3.
|Application ||WB, E|
|Calculated MW||47916 Da|
|Other Names||Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3|
|Target/Specificity||GATA3 (NP_001002295.1, 103 a.a. ~ 200 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GATA3 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Yao X, et al. Chin Med J (Engl), 2010 Mar 20. PMID 20368097.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Lck mediates Th2 differentiation through effects on T-bet and GATA-3. Kemp KL, et al. J Immunol, 2010 Apr 15. PMID 20237292.GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition. Yan W, et al. J Biol Chem, 2010 Apr 30. PMID 20189993.
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