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GCLM Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a full-length recombinant GCLM.

     
  • WB - GCLM Antibody (monoclonal) (M02) AT2178a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (55.88 KDa) .
    detail
  • WB - GCLM Antibody (monoclonal) (M02) AT2178a
    GCLM monoclonal antibody (M02), clone 2C6. Western Blot analysis of GCLM expression in PC-12 ( (Cat # AT2178a )
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P48507
Other Accession BC041809
Reactivity Human, Rat
Host mouse
Clonality Monoclonal
Isotype IgG2a Lambda
Clone Names 2C6
Calculated MW 30727 Da
Additional Information
Gene ID 2730
Other Names Glutamate--cysteine ligase regulatory subunit, GCS light chain, Gamma-ECS regulatory subunit, Gamma-glutamylcysteine synthetase regulatory subunit, Glutamate--cysteine ligase modifier subunit, GCLM, GLCLR
Target/Specificity GCLM (AAH41809, 1 a.a. ~ 274 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsGCLM Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

References

Assessing oxidative pathway genes as risk factors for bipolar disorder. Fullerton JM, et al. Bipolar Disord, 2010 Aug. PMID 20712757.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients. Katakami N, et al. Atherosclerosis, 2010 Jun 12. PMID 20598694.Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. Wang Y, et al. J Hum Genet, 2010 Aug. PMID 20485444.Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. Moyer AM, et al. Cancer Epidemiol Biomarkers Prev, 2010 Mar. PMID 20200426.

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$ 350.00
Cat# AT2178a
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