GCM1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant GCM1.
|Application ||WB, IF, E|
|Calculated MW||49268 Da|
|Other Names||Chorion-specific transcription factor GCMa, hGCMa, GCM motif protein 1, Glial cells missing homolog 1, GCM1, GCMA|
|Target/Specificity||GCM1 (NP_003634, 108 a.a. ~ 166 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GCM1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy. Woo KT, et al. Ann Acad Med Singapore, 2009 Oct. PMID 19890582.Syncytin-1 and glial cells missing a: hypoxia-induced deregulated gene expression along with disordered cell fusion in primary term human trophoblasts. Wich C, et al. Gynecol Obstet Invest, 2009. PMID 19321927.Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast. Baczyk D, et al. Cell Death Differ, 2009 May. PMID 19219068.Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Chapuis J, et al. Mol Psychiatry, 2009 Nov. PMID 19204726.Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. Chiang MH, et al. Biol Reprod, 2008 Nov. PMID 18703417.
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