GHRL Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GHRL.
|Application ||WB, IHC, E|
|Calculated MW||12911 Da|
|Other Names||Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46, Ghrelin-27, Ghrelin-28, Ghrelin, Obestatin, GHRL, MTLRP|
|Target/Specificity||GHRL (AAH25791.1, 1 a.a. ~ 117 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GHRL Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression.
1.Mapping of Ghrelin Gene Expression and Cell Distribution in the Stomach of Morbidly Obese Patients-a Possible Guide for Efficient Sleeve Gastrectomy Construction.Goitein D, Lederfein D, Tzioni R, Berkenstadt H, Venturero M, Rubin M.Obes Surg. 2012 Jan 10. [Epub ahead of print]
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