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GNB3 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant GNB3.

  • WB - GNB3 Antibody (monoclonal) (M01) AT2228a
    GNB3 monoclonal antibody (M01), clone M1-1-1D5 Western Blot analysis of GNB3 expression in HepG2 ( Cat # L019V1 ).
  • IF - GNB3 Antibody (monoclonal) (M01) AT2228a
    Immunofluorescence of monoclonal antibody to GNB3 on HepG2 cell. [antibody concentration 10 ug/ml]
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16520
Other Accession BC002454
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names M1-1-1D5
Calculated MW 37221 Da
Additional Information
Gene ID 2784
Other Names Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, Transducin beta chain 3, GNB3
Target/Specificity GNB3 (AAH02454, 1 a.a. ~ 340 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsGNB3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.


C825T polymorphism of the GNB3 gene on valproate-related metabolic abnormalities in bipolar disorder patients. Chang HH, et al. J Clin Psychopharmacol, 2010 Oct. PMID 20814328.Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Sarzynski MA, et al. Int J Obes (Lond), 2010 Aug 24. PMID 20733583.A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. Fushan AA, et al. Chem Senses, 2010 Sep. PMID 20660057.Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine. Gentile G, et al. J Headache Pain, 2010 Oct. PMID 20652353.

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$ 315.00
Cat# AT2228a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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