GNB3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GNB3.
|Application ||WB, IF|
|Calculated MW||37221 Da|
|Other Names||Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, Transducin beta chain 3, GNB3|
|Target/Specificity||GNB3 (AAH02454, 1 a.a. ~ 340 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GNB3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
C825T polymorphism of the GNB3 gene on valproate-related metabolic abnormalities in bipolar disorder patients. Chang HH, et al. J Clin Psychopharmacol, 2010 Oct. PMID 20814328.Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Sarzynski MA, et al. Int J Obes (Lond), 2010 Aug 24. PMID 20733583.A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. Fushan AA, et al. Chem Senses, 2010 Sep. PMID 20660057.Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine. Gentile G, et al. J Headache Pain, 2010 Oct. PMID 20652353.
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