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GPNMB Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant GPNMB.

  • WB - GPNMB Antibody (monoclonal) (M01) AT2244a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • E - GPNMB Antibody (monoclonal) (M01) AT2244a
    Detection limit for recombinant GST tagged GPNMB is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14956
Other Accession NM_001005340
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 1A8
Calculated MW 63923 Da
Additional Information
Gene ID 10457
Other Names Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB
Target/Specificity GPNMB (NP_001005340, 104 a.a. ~ 203 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsGPNMB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.


1.GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity.Fiorentini C, Bodei S, Bedussi F, Fragni M, Bonini SA, Simeone C, Zani D, Berruti A, Missale C, Memo M, Spano P, Sigala SExp Cell Res. 2014 Feb 28. pii: S0014-4827(14)00088-3. doi: 10.1016/j.yexcr.2014.02.025.2.Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension.Kompass KS, Agapova OA, Li W, Kaufman PL, Rasmussen CA, Hernandez MR.BMC Neurosci. 2008 Sep 26;9:93.

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$ 315.00
Cat# AT2244a
(40 western blots)
Availability: 7-10 days
Bulk Size
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