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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GRB10 Antibody (monoclonal) (M01)   

GRB10 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant GRB10.

  • WB - GRB10 Antibody (monoclonal) (M01) AT2257a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.64 KDa) .
  • WB - GRB10 Antibody (monoclonal) (M01) AT2257a
    GRB10 monoclonal antibody (M01), clone 1A7. Western Blot analysis of GRB10 expression in IMR-32.
  • E - GRB10 Antibody (monoclonal) (M01) AT2257a
    Detection limit for recombinant GST tagged GRB10 is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13322
Other Accession BC024285
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 1A7
Calculated MW 67231 Da
Additional Information
Gene ID 2887
Other Names Growth factor receptor-bound protein 10, GRB10 adapter protein, Insulin receptor-binding protein Grb-IR, GRB10, GRBIR, KIAA0207
Target/Specificity GRB10 (AAH24285, 61 a.a. ~ 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsGRB10 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.


Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Depetris RS, et al. Nat Struct Mol Biol, 2009 Aug. PMID 19648926.Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression. Monk D, et al. Hum Mol Genet, 2009 Aug 15. PMID 19487367.Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Barrett JC, et al. Nat Genet, 2009 Jun. PMID 19430480.Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations. Rampersaud E, et al. Diabetes, 2007 Dec. PMID 17846126.Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Wu C, et al. Proteomics, 2007 Jun. PMID 17474147.

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$ 315.00
Cat# AT2257a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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