GRHPR Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GRHPR.
|Application ||WB, E|
|Calculated MW||35668 Da|
|Other Names||Glyoxylate reductase/hydroxypyruvate reductase, GRHPR, GLXR|
|Target/Specificity||GRHPR (AAH00605, 1 a.a. ~ 328 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GRHPR Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling. Levin-Iaina N, et al. J Urol, 2009 May. PMID 19296982.A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2. Takayama T, et al. Nephrol Dial Transplant, 2007 Aug. PMID 17510093.Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. Booth MP, et al. J Mol Biol, 2006 Jun 30. PMID 16756993.The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.Primary hyperoxaluria: from gene defects to designer drugs? Danpure CJ. Nephrol Dial Transplant, 2005 Aug. PMID 15956068.
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