HDAC8 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant HDAC8.
|Application ||WB, IF, E|
|Calculated MW||41758 Da|
|Other Names||Histone deacetylase 8, HD8, HDAC8, HDACL1|
|Target/Specificity||HDAC8 (AAH50433, 1 a.a. ~ 377 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HDAC8 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . Dowling DP, et al. Biochemistry, 2010 Jun 22. PMID 20545365.Activation and inhibition of histone deacetylase 8 by monovalent cations. Gantt SL, et al. J Biol Chem, 2010 Feb 26. PMID 20029090.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Novel structural insights into class I and II histone deacetylases. Ficner R. Curr Top Med Chem, 2009. PMID 19355988.
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