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HERC4 Antibody (monoclonal) (M08)

Mouse monoclonal antibody raised against a partial recombinant HERC4.

  • WB - HERC4 Antibody (monoclonal) (M08) AT2352a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • E - HERC4 Antibody (monoclonal) (M08) AT2352a
    Detection limit for recombinant GST tagged HERC4 is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5GLZ8
Other Accession NM_022079
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2G7
Calculated MW 118563 Da
Additional Information
Gene ID 26091
Other Names Probable E3 ubiquitin-protein ligase HERC4, 632-, HECT domain and RCC1-like domain-containing protein 4, HERC4, KIAA1593
Target/Specificity HERC4 (NP_071362, 341 a.a. ~ 440 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsHERC4 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).


Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B. Hochrainer K, et al. Cell Mol Life Sci, 2008 Jul. PMID 18535780.A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451.The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. Hochrainer K, et al. Genomics, 2005 Feb. PMID 15676274.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

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$ 315.00
Cat# AT2352a
(40 western blots)
Availability: 7-10 days
Bulk Size
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