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HEXA Antibody (monoclonal) (M06)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT2356a | 0.05 mg 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
HEXA Antibody (monoclonal) (M06) - Product info | |
| Application | WB
|
| Primary Accession | P06865 |
| Reactivity | Human |
| Concentration | 0.5 mg/ml |
| Isotype | IgG1 Kappa |
| Clone Names | 3D1 |
| Calculated MW | 60703 Da |
HEXA Antibody (monoclonal) (M06) - Additional info | |
| Gene ID 3073 | |
| Other Names MGC99608, TSD hexosaminidase A (alpha polypeptide) | |
| Target/Specificity HEXA (AAH18927, 1 a.a. ~ 530 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions HEXA Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. | |
HEXA Antibody (monoclonal) (M06) - Related products
AP6942a: HEXA Antibody (N-term)
AP6942c: HEXA Antibody (Center)
DC04769: Human HEXA cDNA Clone
LY11570a: HEXA Over-expression Lysate
BP6942a: HEXA Antibody (N-term) Blocking Peptide
HEXA Antibody (monoclonal) (M06) - Application data
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Western Blot analysis of HEXA expression in transfected 293T cell line by HEXA monoclonal antibody (M06), clone 3D1. Lane 1: HEXA transfected lysate(60.7 KDa). Lane 2: Non-transfected lysate.
HEXA Antibody (monoclonal) (M06) - Research Areas
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BACKGROUND
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
REFERENCES
Population-based Tay-Sachs screening among Ashkenazi Jewish young adults in the 21st century: Hexosaminidase A enzyme assay is essential for accurate testing. Schneider A, et al. Am J Med Genet A, 2009 Nov. PMID 19876898.Improving accuracy of Tay Sachs carrier screening of the non-Jewish population: analysis of 34 carriers and six late-onset patients with HEXA enzyme and DNA sequence analysis. Park NJ, et al. Pediatr Res, 2010 Feb. PMID 19858779.Hexosaminidase as a new potential marker for larynx cancer. Olszewska E, et al. Clin Biochem, 2009 Jul. PMID 19298806.Structural consequences of amino acid substitutions causing Tay-Sachs disease. Ohno K, et al. Mol Genet Metab, 2008 Aug. PMID 18490185.Rapid detection of fetal Mendelian disorders: Tay-Sachs disease. Guetta E, et al. Methods Mol Biol, 2008. PMID 18425478.
