HIP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant HIP1.
|Application ||WB, IHC, IP, E|
|Calculated MW||116221 Da|
|Other Names||Huntingtin-interacting protein 1, HIP-1, Huntingtin-interacting protein I, HIP-I, HIP1|
|Target/Specificity||HIP1 (NP_005329, 928 a.a. ~ 1037 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HIP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined.
Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Wilbur JD, et al. Acta Crystallogr D Biol Crystallogr, 2010 Mar. PMID 20179344.Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Han JW, et al. Nat Genet, 2009 Nov. PMID 19838193.HIP1 exhibits an early recruitment and a late stage function in the maturation of coated pits. Gottfried I, et al. Cell Mol Life Sci, 2009 Sep. PMID 19626275.Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. Wilbur JD, et al. J Biol Chem, 2008 Nov 21. PMID 18790740.Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI). Niu Q, et al. J Mol Biol, 2008 Feb 1. PMID 18155047.
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