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HIP1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant HIP1.

  • WB - HIP1 Antibody (monoclonal) (M01) AT2370a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
  • WB - HIP1 Antibody (monoclonal) (M01) AT2370a
    HIP1 monoclonal antibody (M01), clone 1F12 Western Blot analysis of HIP1 expression in HeLa ( (Cat # AT2370a )
  • WB - HIP1 Antibody (monoclonal) (M01) AT2370a
    Western Blot analysis of HIP1 expression in transfected 293T cell line by HIP1 monoclonal antibody (M01), clone 1F12.

    Lane 1: HIP1 transfected lysate(116.2 KDa).
    Lane 2: Non-transfected lysate.
  • IHC - HIP1 Antibody (monoclonal) (M01) AT2370a
    Immunoperoxidase of monoclonal antibody to HIP1 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]
  • IP - HIP1 Antibody (monoclonal) (M01) AT2370a
    Immunoprecipitation of HIP1 transfected lysate using anti-HIP1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with HIP1 MaxPab rabbit polyclonal antibody.
  • E - HIP1 Antibody (monoclonal) (M01) AT2370a
    Detection limit for recombinant GST tagged HIP1 is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00291
Other Accession NM_005338
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 1F12
Calculated MW 116221 Da
Additional Information
Gene ID 3092
Other Names Huntingtin-interacting protein 1, HIP-1, Huntingtin-interacting protein I, HIP-I, HIP1
Target/Specificity HIP1 (NP_005329, 928 a.a. ~ 1037 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsHIP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined.


Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Wilbur JD, et al. Acta Crystallogr D Biol Crystallogr, 2010 Mar. PMID 20179344.Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Han JW, et al. Nat Genet, 2009 Nov. PMID 19838193.HIP1 exhibits an early recruitment and a late stage function in the maturation of coated pits. Gottfried I, et al. Cell Mol Life Sci, 2009 Sep. PMID 19626275.Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. Wilbur JD, et al. J Biol Chem, 2008 Nov 21. PMID 18790740.Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI). Niu Q, et al. J Mol Biol, 2008 Feb 1. PMID 18155047.

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$ 315.00
Cat# AT2370a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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