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HOXA5 Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant HOXA5.

     
  • IF - HOXA5 Antibody (monoclonal) (M05) AT2405a
    Immunofluorescence of monoclonal antibody to HOXA5 on HeLa cell . [antibody concentration 10 ug/ml]
    detail
  • WB - HOXA5 Antibody (monoclonal) (M05) AT2405a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
    detail
  • E - HOXA5 Antibody (monoclonal) (M05) AT2405a
    Detection limit for recombinant GST tagged HOXA5 is approximately 0.3ng/ml as a capture antibody.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession P20719
Other Accession NM_019102.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4A8
Calculated MW 29345 Da
Additional Information
Gene ID 3202
Other Names Homeobox protein Hox-A5, Homeobox protein Hox-1C, HOXA5, HOX1C
Target/Specificity HOXA5 (NP_061975.1, 171 a.a. ~ 270 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsHOXA5 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.

References

Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. Ester AR, et al. Am J Med Genet A, 2009 Dec. PMID 19938081.Epigenetic inactivation of Homeobox A5 gene in nonsmall cell lung cancer and its relationship with clinicopathological features. Kim DS, et al. Mol Carcinog, 2009 Dec. PMID 19554572.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.Clinical significance of promoter hypermethylation of RASSF1A, RARbeta2, BRCA1 and HOXA5 in breast cancers of Indian patients. Bagadi SA, et al. Life Sci, 2008 Jun 20. PMID 18538349.Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Chen Y, et al. Blood, 2008 Feb 1. PMID 17957028.

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$ 350.00
Cat# AT2405a
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Availability: 7-10 days
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