HOXB5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant HOXB5.
|Application ||WB, E|
|Calculated MW||29434 Da|
|Other Names||Homeobox protein Hox-B5, Homeobox protein HHOC10, Homeobox protein Hox-2A, Homeobox protein Hu-1, HOXB5, HOX2A|
|Target/Specificity||HOXB5 (NP_002138.1, 170 a.a. ~ 267 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HOXB5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.
DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. Wu Q, et al. Mol Cancer, 2007 Jul 10. PMID 17623056.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Expression of Hoxb-5 during human lung development and in congenital lung malformations. Volpe MV, et al. Birth Defects Res A Clin Mol Teratol, 2003 Aug. PMID 14632303.HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts. Fu M, et al. Dev Dyn, 2003 Sep. PMID 12950074.HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells. Wu Y, et al. Mol Cell Biol, 2003 Aug. PMID 12897140.
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