HOXB7 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant HOXB7.
|Application ||WB, E|
|Calculated MW||24015 Da|
|Other Names||Homeobox protein Hox-B7, Homeobox protein HHOC1, Homeobox protein Hox-2C, HOXB7, HOX2C|
|Target/Specificity||HOXB7 (NP_004493, 55 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HOXB7 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.
Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. De Souza Setubal Destro MF, et al. Int J Oncol, 2010 Jan. PMID 19956843.Differential expression of HOXB7 gene in multiple myeloma and extramedullary multiple myeloma patients. Novak EM, et al. Eur J Haematol, 2010 Feb 1. PMID 19878270.Inhibition of 13-cis retinoic acid-induced gene expression of homeobox B7 by thalidomide. Milanovi? D, et al. Int J Cancer, 2007 Sep 15. PMID 17514648.A role for the HOXB7 homeodomain protein in DNA repair. Rubin E, et al. Cancer Res, 2007 Feb 15. PMID 17308091.Correlation between genetic variations in Hox clusters and Hirschsprung's disease. Garcia-Barcel? MM, et al. Ann Hum Genet, 2007 Jul. PMID 17274802.
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