HOXB9 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a full-length recombinant HOXB9.
|Application ||WB, E|
|Calculated MW||28059 Da|
|Other Names||Homeobox protein Hox-B9, Homeobox protein Hox-25, Homeobox protein Hox-2E, HOXB9, HOX2E|
|Target/Specificity||HOXB9 (NP_076922.1, 65 a.a. ~ 163 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HOXB9 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.
HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. Hayashida T, et al. Proc Natl Acad Sci U S A, 2010 Jan 19. PMID 20080567.A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545.WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Nguyen DX, et al. Cell, 2009 Jul 10. PMID 19576624.Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. Rouault K, et al. Osteoarthritis Cartilage, 2009 Aug. PMID 19341834.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.
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