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>   home   >   Products   >   Primary Antibodies   >   HOXC4 Antibody (monoclonal) (M02)   

HOXC4 Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant HOXC4.

  • WB - HOXC4 Antibody (monoclonal) (M02) AT2422a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.29 KDa) .
  • WB - HOXC4 Antibody (monoclonal) (M02) AT2422a
    HOXC4 monoclonal antibody (M02), clone 2D6 Western Blot analysis of HOXC4 expression in K-562 ( (Cat # AT2422a )
  • IF - HOXC4 Antibody (monoclonal) (M02) AT2422a
    Immunofluorescence of monoclonal antibody to HOXC4 on HeLa cell. [antibody concentration 10 ug/ml]
  • E - HOXC4 Antibody (monoclonal) (M02) AT2422a
    Detection limit for recombinant GST tagged HOXC4 is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09017
Other Accession NM_153633
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2D6
Calculated MW 29811 Da
Additional Information
Gene ID 3221
Other Names Homeobox protein Hox-C4, Homeobox protein CP19, Homeobox protein Hox-3E, HOXC4, HOX3E
Target/Specificity HOXC4 (NP_705897, 160 a.a. ~ 264 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsHOXC4 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.


HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Park SR, et al. Nat Immunol, 2009 May. PMID 19363484.The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Wissm?ller S, et al. Nucleic Acids Res, 2006. PMID 16582099.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. Gong LG, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2005 Oct. PMID 16215934.A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Speleman F, et al. Leukemia, 2005 Mar. PMID 15674412.

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$ 315.00
Cat# AT2422a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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