HOXC9 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant HOXC9.
|Calculated MW||29248 Da|
|Other Names||Homeobox protein Hox-C9, Homeobox protein Hox-3B, HOXC9, HOX3B|
|Target/Specificity||HOXC9 (AAH53894, 1 a.a. ~ 260 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HOXC9 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.
RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. Lin Q, et al. J Cancer Res Clin Oncol, 2009 Dec. PMID 19506903.Search for cellular partners of human papillomavirus type 16 E2 protein. Olejnik-Schmidt AK, et al. Arch Virol, 2008. PMID 18305892.Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes. Okamoto OK, et al. Biochim Biophys Acta, 2007 Jul-Aug. PMID 17588684.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Luo L, et al. Nature, 2004 Feb 19. PMID 14973489.
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