ID1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant ID1.
|Application ||WB, IF, E|
|Calculated MW||16133 Da|
|Other Names||DNA-binding protein inhibitor ID-1, Class B basic helix-loop-helix protein 24, bHLHb24, Inhibitor of DNA binding 1, Inhibitor of differentiation 1, ID1, BHLHB24, ID|
|Target/Specificity||ID1 (AAH00613.1, 1 a.a. ~ 155 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ID1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Yang J, et al. Circ Res, 2010 Jul 23. PMID 20522807.Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas. Phi JH, et al. J Neurosurg Pediatr, 2010 Jun. PMID 20515335.ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. Geng H, et al. Cancer Res, 2010 Apr 15. PMID 20388787.The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. Philipot O, et al. PLoS One, 2010 Feb 25. PMID 20195544.Inhibitor of differentiation 1 (ID1) promotes cell survival and proliferation of prostate epithelial cells. Schmidt M, et al. Cell Mol Biol Lett, 2010 Jun. PMID 20186495.
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