IL1RN Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant IL1RN.
|Application ||WB, E|
|Calculated MW||20055 Da|
|Other Names||Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra, IL1RN, IL1F3, IL1RA|
|Target/Specificity||IL1RN (AAH09745, 1 a.a. ~ 159 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||IL1RN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. Giroux S, et al. Bone, 2010 Jul 30. PMID 20654748.[Correlation of IL-1beta-511 and IL-1RN VNTR gene polymorphism to coronary heart disease: a Meta-analysis.] Chen F, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2010 Jul. PMID 20650788.Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis. Kupcinskas L, et al. Eur J Gastroenterol Hepatol, 2010 Oct. PMID 20631624.Interleukin-1A +4845(G>T) polymorphism is a factor predisposing to acne vulgaris. Szab? K, et al. Tissue Antigens, 2010 Jul 11. PMID 20630038.
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