IL23R Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant IL23R.
|Application ||WB, E|
|Calculated MW||71722 Da|
|Other Names||Interleukin-23 receptor, IL-23 receptor, IL-23R, IL23R|
|Target/Specificity||IL23R (NP_653302, 553 a.a. ~ 628 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||IL23R Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Toll-like receptor 9, NOD2 and IL23R gene polymorphisms influenced outcome in AML patients transplanted from HLA-identical sibling donors. Elmaagacli AH, et al. Bone Marrow Transplant, 2010 Jul 12. PMID 20622911.Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh?et's disease susceptibility loci. Mizuki N, et al. Nat Genet, 2010 Aug. PMID 20622879.Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh?et's disease. Remmers EF, et al. Nat Genet, 2010 Aug. PMID 20622878.A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population. Chen J, et al. Mol Carcinog, 2010 Oct. PMID 20607725.
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