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IL23R Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant IL23R.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q5VWK5 |
| Other Accession | NM_144701 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3D7 |
| Calculated MW | 71722 Da |
| Gene ID | 149233 |
|---|---|
| Other Names | Interleukin-23 receptor, IL-23 receptor, IL-23R, IL23R |
| Target/Specificity | IL23R (NP_653302, 553 a.a. ~ 628 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | IL23R Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
References
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Toll-like receptor 9, NOD2 and IL23R gene polymorphisms influenced outcome in AML patients transplanted from HLA-identical sibling donors. Elmaagacli AH, et al. Bone Marrow Transplant, 2010 Jul 12. PMID 20622911.Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh?et's disease susceptibility loci. Mizuki N, et al. Nat Genet, 2010 Aug. PMID 20622879.Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh?et's disease. Remmers EF, et al. Nat Genet, 2010 Aug. PMID 20622878.A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population. Chen J, et al. Mol Carcinog, 2010 Oct. PMID 20607725.
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