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>   home   >   Products   >   Primary Antibodies   >   ING3 Antibody (monoclonal) (M01)   

ING3 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant ING3.

  • WB - ING3 Antibody (monoclonal) (M01) AT2533a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.86 KDa) .
  • WB - ING3 Antibody (monoclonal) (M01) AT2533a
    ING3 monoclonal antibody (M01), clone 2E9. Western Blot analysis of ING3 expression in Hela S3 NE ( (Cat # AT2533a )
  • E - ING3 Antibody (monoclonal) (M01) AT2533a
    Detection limit for recombinant GST tagged ING3 is 0.1 ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NXR8
Other Accession NM_198267
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2E10
Calculated MW 46743 Da
Additional Information
Gene ID 54556
Other Names Inhibitor of growth protein 3, p47ING3, ING3
Target/Specificity ING3 (NP_938008, 1 a.a. ~ 92 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsING3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.


The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system. Chen G, et al. Oncogene, 2010 Mar 11. PMID 19935701.High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Maestrini E, et al. Mol Psychiatry, 2010 Sep. PMID 19401682.Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer. Gunduz M, et al. Cancer Sci, 2008 Mar. PMID 18081876.Prognostic significance of nuclear ING3 expression in human cutaneous melanoma. Wang Y, et al. Clin Cancer Res, 2007 Jul 15. PMID 17634537.ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974.

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$ 315.00
Cat# AT2533a
(40 western blots)
Availability: 7-10 days
Bulk Size
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