IQGAP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant IQGAP1.
|Application ||WB, IHC, IF, E|
|Calculated MW||189252 Da|
|Other Names||Ras GTPase-activating-like protein IQGAP1, p195, IQGAP1, KIAA0051|
|Target/Specificity||IQGAP1 (NP_003861, 611 a.a. ~ 710 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||IQGAP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
Honokiol inhibits HepG2 migration via down-regulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis. Liang S, et al. Proteomics, 2010 Apr. PMID 20127691.Endothelial IQGAP1 regulates efficient lymphocyte transendothelial migration. Nakhaei-Nejad M, et al. Eur J Immunol, 2010 Jan. PMID 20017185.Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis-critical role in tumor invasion. Hayashi H, et al. Int J Cancer, 2010 Jun 1. PMID 19856315.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway. Wang JB, et al. J Cell Sci, 2009 Jun 15. PMID 19454477.
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