IRF5 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant IRF5.
|Application ||WB, IHC, IF|
|Calculated MW||56044 Da|
|Other Names||Interferon regulatory factor 5, IRF-5, IRF5|
|Target/Specificity||IRF5 (NP_002191, 395 a.a. ~ 504 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||IRF5 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Liu X, et al. Nat Genet, 2010 Aug. PMID 20639880.Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Hirschfield GM, et al. Nat Genet, 2010 Aug. PMID 20639879.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Genetic Differences between Five European Populations. Moskvina V, et al. Hum Hered, 2010 Jul 8. PMID 20616560.Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.
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