IRX5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant IRX5.
|Application ||WB, IF, E|
|Calculated MW||50361 Da|
|Other Names||Iroquois-class homeodomain protein IRX-5, Homeodomain protein IRX-2A, Homeodomain protein IRXB2, Iroquois homeobox protein 5, IRX5, IRX2A, IRXB2|
|Target/Specificity||IRX5 (NP_005844, 204 a.a. ~ 264 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||IRX5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells. Myrthue A, et al. Clin Cancer Res, 2008 Jun 1. PMID 18519790.A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. Kanno S, et al. EMBO J, 2007 Apr 18. PMID 17396150.[Irx5: a transcription factor that regulates the cardiac repolarization gradient] Bruneau BG. Med Sci (Paris), 2006 Mar. PMID 16527195.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. Ogura K, et al. Cytogenet Cell Genet, 2001. PMID 11435706.
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