ISL1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ISL1.
|Calculated MW||39036 Da|
|Other Names||Insulin gene enhancer protein ISL-1, Islet-1, ISL1|
|Target/Specificity||ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ISL1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle. De Luca A, et al. Clin Genet, 2010 Aug 2. PMID 20807224.Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. Stevens KN, et al. PLoS One, 2010 May 26. PMID 20520780.A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Davis OS, et al. Behav Genet, 2010 Mar 21. PMID 20306291.Early first trimester human embryonic cardiac Islet-1 progenitor cells and cardiomyocytes: Immunohistochemical and electrophysiological characterization. Genead R, et al. Stem Cell Res, 2010 Jan. PMID 19896915.The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2. Zhang H, et al. J Mol Biol, 2009 Sep 25. PMID 19619559.
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