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JAM2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant JAM2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P57087 |
| Other Accession | BC017779 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1G4 |
| Calculated MW | 33207 Da |
| Gene ID | 58494 |
|---|---|
| Other Names | Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM |
| Target/Specificity | JAM2 (AAH17779, 29 a.a. ~ 298 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | JAM2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
References
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545.Expression of junctional adhesion molecules on the human lymphatic endothelium. Ueki T, et al. Microvasc Res, 2008 Mar. PMID 17822725.The role of junctional adhesion molecules in vascular inflammation. Weber C, et al. Nat Rev Immunol, 2007 Jun. PMID 17525755.A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. Iden S, et al. EMBO Rep, 2006 Dec. PMID 17057644.The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.
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