JARID1A Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant JARID1A.
|Application ||WB, E|
|Calculated MW||192095 Da|
|Other Names||Lysine-specific demethylase 5A, 11411-, Histone demethylase JARID1A, Jumonji/ARID domain-containing protein 1A, Retinoblastoma-binding protein 2, RBBP-2, KDM5A, JARID1A, RBBP2, RBP2|
|Target/Specificity||JARID1A (NP_005047, 191 a.a. ~ 290 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||JARID1A Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein.
Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. Ge Z, et al. FASEB J, 2010 Feb. PMID 19762557. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Wang GG, et al. Nature, 2009 Jun 11. PMID 19430464. Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Lopez-Bigas N, et al. Mol Cell, 2008 Aug 22. PMID 18722178. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348. RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. Hayakawa T, et al. Genes Cells, 2007 Jun. PMID 17573780.
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