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KCNE1 Antibody (monoclonal) (M13)

Mouse monoclonal antibody raised against a full length recombinant KCNE1.

     
  • IP - KCNE1 Antibody (monoclonal) (M13) AT2593a
    Immunoprecipitation of KCNE1 transfected lysate using anti-KCNE1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with KCNE1 MaxPab rabbit polyclonal antibody.
    detail
  • E - KCNE1 Antibody (monoclonal) (M13) AT2593a
    Detection limit for recombinant GST tagged KCNE1 is approximately 3ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IP, E
Primary Accession P15382
Other Accession BC036452
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2A6
Calculated MW 14675 Da
Additional Information
Gene ID 3753
Other Names Potassium voltage-gated channel subfamily E member 1, Delayed rectifier potassium channel subunit IsK, IKs producing slow voltage-gated potassium channel subunit beta Mink, Minimal potassium channel, KCNE1
Target/Specificity KCNE1 (AAH36452, 1 a.a. ~ 105 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsKCNE1 Antibody (monoclonal) (M13) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.

References

Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Causes of hearing impairment in the Norwegian paediatric cochlear implant program. Siem G, et al. Int J Audiol, 2010 Aug. PMID 20553101.Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1. Lvov A, et al. J Gen Physiol, 2010 Jun. PMID 20479109.L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. Yokoyama K, et al. Nephron Clin Pract, 2010. PMID 20424473.Common variants in cardiac ion channel genes are associated with sudden cardiac death. Albert CM, et al. Circ Arrhythm Electrophysiol, 2010 Jun 1. PMID 20400777.

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$ 350.00
Cat# AT2593a
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