KCNJ15 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant KCNJ15.
|Application ||WB, E|
|Calculated MW||42577 Da|
|Other Names||ATP-sensitive inward rectifier potassium channel 15, Inward rectifier K(+) channel Kir13, Inward rectifier K(+) channel Kir42, Potassium channel, inwardly rectifying subfamily J member 15, KCNJ15, KCNJ14|
|Target/Specificity||KCNJ15 (NP_002234, 290 a.a. ~ 355 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KCNJ15 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Three transcript variants encoding the same protein have been found for this gene.
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Okamoto K, et al. Am J Hum Genet, 2010 Jan. PMID 20085713.MUPP1 complexes renal K+ channels to alter cell surface expression and whole cell currents. Sindic A, et al. Am J Physiol Renal Physiol, 2009 Jul. PMID 19420109.Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Ji W, et al. Nat Genet, 2008 May. PMID 18391953.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. Huang C, et al. Am J Physiol Renal Physiol, 2007 Mar. PMID 17122384.
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