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KLF12 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant KLF12.

     
  • WB - KLF12 Antibody (monoclonal) (M01) AT2630a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.64 KDa) .
    detail
  • WB - KLF12 Antibody (monoclonal) (M01) AT2630a
    Western Blot analysis of KLF12 expression in transfected 293T cell line by KLF12 monoclonal antibody (M01), clone 3E4.

    Lane 1: KLF12 transfected lysate(44.2 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9Y4X4
Other Accession NM_007249
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3E5
Calculated MW 44240 Da
Additional Information
Gene ID 11278
Other Names Krueppel-like factor 12, Transcriptional repressor AP-2rep, KLF12, AP2REP
Target/Specificity KLF12 (NP_009180, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsKLF12 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.

References

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Petersen GM, et al. Nat Genet, 2010 Mar. PMID 20101243.A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis. Wieczorek S, et al. J Mol Med, 2010 Apr. PMID 20049410.No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort. Eyre S, et al. Ann Rheum Dis, 2010 Jul. PMID 19907058.Kr?ppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression. Nakamura Y, et al. Int J Cancer, 2009 Oct 15. PMID 19588488.

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$ 350.00
Cat# AT2630a
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Availability: 7-10 days
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