KLF8 Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant KLF8.
|Application ||WB, E|
|Calculated MW||39314 Da|
|Other Names||Krueppel-like factor 8, Basic krueppel-like factor 3, Zinc finger protein 741, KLF8, BKLF3, ZNF741|
|Target/Specificity||KLF8 (NP_009181.1, 1 a.a. ~ 98 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KLF8 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.
Small interference RNA targeting Kr?ppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. Fu WJ, et al. J Cancer Res Clin Oncol, 2010 Aug. PMID 20182889.Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. Wang X, et al. J Biol Chem, 2008 May 16. PMID 18353772.Kr?ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Wang X, et al. Cancer Res, 2007 Aug 1. PMID 17671186.Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation. Hu JH, et al. J Mol Biol, 2007 Mar 2. PMID 17224162.KLF8 transcription factor participates in oncogenic transformation. Wang X, et al. Oncogene, 2007 Jan 18. PMID 16832343.
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