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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KRT5 Antibody (monoclonal) (M08)   

KRT5 Antibody (monoclonal) (M08)

Mouse monoclonal antibody raised against a full-length recombinant KRT5.

  • WB - KRT5 Antibody (monoclonal) (M08) AT2660a
    Western Blot analysis of KRT5 expression in transfected 293T cell line by KRT5 monoclonal antibody (M08), clone 1A12.

    Lane 1: KRT5 transfected lysate(62.4 KDa).
    Lane 2: Non-transfected lysate.
  • IP - KRT5 Antibody (monoclonal) (M08) AT2660a
    Immunoprecipitation of KRT5 transfected lysate using anti-KRT5 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with KRT5 MaxPab rabbit polyclonal antibody.
  • E - KRT5 Antibody (monoclonal) (M08) AT2660a
    Detection limit for recombinant GST tagged KRT5 is 0.3 ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13647
Other Accession BC024292
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 1A12
Calculated MW 62378 Da
Additional Information
Gene ID 3852
Other Names Keratin, type II cytoskeletal 5, 58 kDa cytokeratin, Cytokeratin-5, CK-5, Keratin-5, K5, Type-II keratin Kb5, KRT5
Target/Specificity KRT5 (AAH24292, 1 a.a. ~ 590 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsKRT5 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.


The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation. L?ffek S, et al. Hum Mutat, 2010 Apr. PMID 20151404.Epidermolysis bullosa simplex due to KRT5 mutations: mutation-related differences in cellular fragility and the protective effects of trimethylamine N-oxide in cultured primary keratinocytes. Chamcheu JC, et al. Br J Dermatol, 2010 May. PMID 20128788.Novel and recurrent mutations in Keratin 5 and 14 in Korean patients with Epidermolysis bullosa simplex. Kang TW, et al. J Dermatol Sci, 2010 Feb. PMID 20060687.Keratin mutations in patients with epidermolysis bullosa simplex: correlations between phenotype severity and disturbance of intermediate filament molecular structure. Jer?bkov? B, et al. Br J Dermatol, 2010 May. PMID 20030639.ERK involvement in resistance to apoptosis in keratinocytes with mutant keratin. Russell D, et al. J Invest Dermatol, 2010 Mar. PMID 19847192.

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$ 315.00
Cat# AT2660a
(40 western blots)
Availability: 7-10 days
Bulk Size
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