LASP1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full-length recombinant LASP1.
|Calculated MW||29717 Da|
|Other Names||LIM and SH3 domain protein 1, LASP-1, Metastatic lymph node gene 50 protein, MLN 50, LASP1, MLN50|
|Target/Specificity||LASP1 (AAH12460, 1 a.a. ~ 261 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||LASP1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of a LIM protein subfamily characterized by a LIM motif and a domain of Src homology region 3. The encoded protein functions as an actin-binding protein and possibly in cytoskeletal organization.
Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. Frietsch JJ, et al. Br J Cancer, 2010 May 25. PMID 20461080.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase. Traenka J, et al. Thromb Haemost, 2009 Sep. PMID 19718473.Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells. Salvi A, et al. Neoplasia, 2009 Feb. PMID 19177205.LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma. Wang B, et al. J Hepatol, 2009 Mar. PMID 19155088.
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