LDLRAP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant LDLRAP1.
|Application ||WB, IHC, IF, E|
|Calculated MW||33885 Da|
|Other Names||Low density lipoprotein receptor adapter protein 1, Autosomal recessive hypercholesterolemia protein, LDLRAP1, ARH|
|Target/Specificity||LDLRAP1 (AAH29770, 1 a.a. ~ 263 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||LDLRAP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
1.Disabled-2 Protein Facilitates Assembly Polypeptide-2-independent Recruitment of Cystic Fibrosis Transmembrane Conductance Regulator to Endocytic Vesicles in Polarized Human Airway Epithelial Cells.Cihil KM, Ellinger P, Fellows A, Stolz DB, Madden DR, Swiatecka-Urban A.J Biol Chem. 2012 Apr 27;287(18):15087-99. Epub 2012 Mar 7.2.Autosomal recessive hypercholesterolemia in Spanish kindred due to a large deletion in the ARH gene.Quagliarini F, Vallve JC, Campagna F, Alvaro A, Fuentes-Jimenez FJ, Sirinian MI, Meloni F, Masana L, Arca M.Mol Genet Metab. 2007 Nov;92(3):243-8. Epub 2007 Aug 7.
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