LGALS8 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant LGALS8.
|Application ||WB, E|
|Calculated MW||35808 Da|
|Other Names||Galectin-8, Gal-8, Po66 carbohydrate-binding protein, Po66-CBP, Prostate carcinoma tumor antigen 1, PCTA-1, LGALS8|
|Target/Specificity||LGALS8 (AAH15818, 1 a.a. ~ 358 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||LGALS8 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.
Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7. Cludts S, et al. Anticancer Res, 2009 Dec. PMID 20044599.Crystallization and preliminary X-ray diffraction analysis of a protease-resistant mutant form of human galectin-8. Yoshida H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 May 1. PMID 19407390.Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Massardo L, et al. Lupus, 2009 May. PMID 19395456.Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. Cueni LN, et al. Exp Cell Res, 2009 Jun 10. PMID 19268462.Evaluation of galectin-8 expression in thyroid tumors. Savin S, et al. Med Oncol, 2009. PMID 19009371.
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