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LGALS8 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant LGALS8.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O00214 |
| Other Accession | BC015818 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 3E6 |
| Calculated MW | 35808 Da |
| Gene ID | 3964 |
|---|---|
| Other Names | Galectin-8, Gal-8, Po66 carbohydrate-binding protein, Po66-CBP, Prostate carcinoma tumor antigen 1, PCTA-1, LGALS8 |
| Target/Specificity | LGALS8 (AAH15818, 1 a.a. ~ 358 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | LGALS8 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7. Cludts S, et al. Anticancer Res, 2009 Dec. PMID 20044599.Crystallization and preliminary X-ray diffraction analysis of a protease-resistant mutant form of human galectin-8. Yoshida H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 May 1. PMID 19407390.Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Massardo L, et al. Lupus, 2009 May. PMID 19395456.Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. Cueni LN, et al. Exp Cell Res, 2009 Jun 10. PMID 19268462.Evaluation of galectin-8 expression in thyroid tumors. Savin S, et al. Med Oncol, 2009. PMID 19009371.
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