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LGMN Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant LGMN.

  • E - LGMN Antibody (monoclonal) (M02) AT2703a
    Detection limit for recombinant GST tagged LGMN is approximately 0.1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99538
Other Accession BC003061
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names M1
Calculated MW 49411 Da
Additional Information
Gene ID 5641
Other Names Legumain, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1
Target/Specificity LGMN (AAH03061.1, 1 a.a. ~ 433 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsLGMN Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.


1.Targeting Cell Surface Alpha(v)beta(3,5) Integrins Increases Therapeutic Efficacies of a Legumain Protease-Activated Auristatin Prodrug.Liu Y, Bajjuri KM, Liu C, Sinha SC.Mol Pharm. 2011 Oct 31.

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$ 315.00
Cat# AT2703a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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